The Technology
Imaging Gene Therapy's Invisible Revolution
Imagining in Real Time
PreDx has developed a unique magnetic resonance (MR) imaging technology for real time reporting of successful gene therapy in living animals. The PreDx technology is based on proprietary MR imaging probes activated in the presence of inserted gene expression products.
Bio-Responsive Contrast Agents
PreDx’s unique bio-responsive contrast agents (BCAs) allow researchers and clinicians to “watch” changes occur in the physiological state of an animal or patient undergoing gene therapy; the BCAs are triggered to turn from “off” to “on” when they encounter the specific enzyme expressed as the result of successful gene therapy.
Real-Time Efficacy Evaluation
This technology non-invasively tracks enzyme activity in vivo after gene therapy. In real time, the BCA's response closely matches the enzyme's activity level and location with a stronger response indicating greater enzyme activity.
Pre-Contrast MR images of mouse brain 30 days post AAV gene therapy.
Post-contrast with agent injection.
A quantitative representative intensity level heat map
