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The Technology
Advanced Imaging for Early Osteoarthritis

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Imagining in Real Time

Senescent cells play a vital role in the pathogenesis of musculoskeletal (MSK) diseases such as osteoarthritis (OA). Cellular senescence in articular joints represents a response to persistent stress leading to cell-cycle arrest and enhanced production of inflammatory cytokines, which perpetuate joint damage. Identifying and mapping these senescent cells in joints and related tissues is crucial for the development of effective treatments.

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Bio-Responsive Contrast Agents

Current methods to detect senescent cells are primarily ex vivo, limiting their utility in longitudinal studies. However, PreDx's advancements in bio-responsive MR imaging agents are paving the way for non-invasive, real-time imaging of senescent cells in vivo. These agents allow for the continuous monitoring of senescent cells in osteoarthritic joints, providing valuable insights into the efficacy of senolytic therapies.

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Real-Time Efficacy Evaluation

By integrating PreDx's innovative imaging biomarkers into clinical practice, we can significantly enhance our ability to diagnose and treat osteoarthritis, offering new hope for patients suffering from this debilitating condition.


Senescent cells (arrow) in superficial cartilage defect of a porcine femur

specimen after incubation with the SA-β-Gal-sensitive Gd-chelate. The senescent cells demonstrate a strong (positive) signal on sagit- tal T1-weighted MR images (arrow), while normal cartilage shows a significantly lower MRI signal.

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